SPECIAL COURSE Tuesday, March 23, 2010   —  8:00 AM - 1:00 PM Thurgood South West ADVANCED MOLECULAR PATHOLOGY Click the button above to add this event to your Itinerary Planner... COURSE DIRECTORS: Frederic G. Barr, M.D., Ph.D. Department of Pathology & Laboratory Medicine University of Pennsylvania School of Medicine Philadelphia, Pennsylvania This special course will provide an in-depth consideration of recent advances in molecular biology and genetics that are enhancing the understanding of the pathogenesis of human cancer and other diseases, and impacting on the practice of diagnostic pathology. Topics will be chosen to highlight specific advances in the molecular and cell biology related to disease pathogenesis, with considerations of molecular mechanisms, genetic and cellular signaling pathways, and various methodologic approaches. The program is designed as an update for both practicing pathologists and primary investigators on these specific topics as well as general trends in the field of molecular pathology. In addition to presenting a basic scientific foundation on each topic, each lecture will provide practical information concerning how this information can be applied in diagnostic and therapeutic settings. Therefore, an important overall emphasis of this course will be translational issues that link basic discoveries with the practice of pathology. AGENDA 8:00 Introduction Frederic G. Barr, M.D., Ph.D., University of Pennsylvania School of Medicine 8:10 Beyond the Human Genome Sequence: Translating Genomic Knowledge into Health Benefits Eric Green, M.D., Ph.D., National Human Genome Research Institute 8:55 The Role of Stroma in Neoplasia Robert B. West, M.D., Ph.D., Stanford University Medical Center 9:40 Molecular Pathology of Breast Cancer Celina G. Kleer, M.D., University of Michigan Medical School 10:25 Coffee break 10:45 Gene Amplification in Cancer - Oncogenic Diversity within a Genetic Mechanism Frederic G. Barr, M.D., Ph.D., University of Pennsylvania School of Medicine 11:30 Embryonic Patterning Pathways in Homeostasis and Cancer David M. Berman, M.D., Ph.D. The Johns Hopkins University Medical School 12:15 Molecular Pathogenesis and Pathology of Malignant Gliomas Hai Yan, M.D., Ph.D., Duke University Medical Center 1:00 Concluding remarks